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Depression disorders are serious medical conditions that need to be treated. Depression affect body, thought, mood causing a lot of sufferings and pain. The disease can affect people independently on age, gender, social status without any significant cause. However, long-term experience in depression study made possible to determine the main risk factors that could provoke depression condition. These are: Stress and trauma, hereditary factors, physical and mental disorders. Also depression is more frequently occurs in people with low self-respect and negative world outlook. All of these conditions cause imbalance of chemicals in the brain called neurotransmitters. The lack of neurotransmitter in the brain leads to disruption in informational transmission between nerve cells resulting in mental diseases including and depression.